Work

Genetic heterogeneity and trans regulators of gene expression

Year: 2007

Type: article

Abstract: Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.

Source: BMC Proceedings

DOI: 10.1186/1753-6561-1-s1-s80

Authors: Laurel A Bastone, Mary E Putt, Thomas R Ten Have, Vivian G Cheung, Richard S Spielman

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,290

Funders: National Institutes of Health, National Human Genome Research Institute, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development