Work

Preinitiation complex assembly: potentially a bumpy path

Year: 1998

Type: review

Abstract: During 1996 and 1997, several chemical issues that arise in the early stages of preinitiation complex (PIC) formation were resolved. Kinetics experiments indicated that both TBP dimerization and DNA bending influence the rate of TBP-TATA box assembly. Affinity cleavage experiments indicated that TBP lacks the specificity to nucleate assembly of a properly oriented PIC. Finally, high-resolution structures provided the atomic detail of early intermediates in PIC formation.

Source: Current Opinion in Chemical Biology

DOI: 10.1016/s1367-5931(98)80030-6

Authors: Julia M Cox, Alexis R Kays, Jennifer F Sanchez, Alanna Schepartz

Institution: Yale University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,510

OpenAlex ID: W1970109655

FWCI: 0.1

Cites: 60

Cited by: 6

Related to: 10