Work

Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals

Year: 2013

Type: article

Abstract: Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: (64)Cu-ATSM, (68)Ga-DOTATOC, (89)Zr-transferrin, (99m)Tc-sestamibi, and (99m)Tc-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.

Source: Inorganic Chemistry

DOI: 10.1021/ic401607z

Authors: Brian M. Zeglis, Jacob L. Houghton, Michael J. Evans, Nerissa Viola-Villegas, Jason S. Lewis

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G3640107383, Biomarkers for predicting response to Hsp90 therapy, G4529081476, Cancer Center Support Grant