Work

The Tumor Suppressor RASSF1A Does not Interact with Cdc20, an Activator of the Anaphase-Promoting Complex

Year: 2007

Type: article

Abstract: It has been reported that the RASSF1A tumor suppressor protein controls mitotic progression by binding to and inhibiting Cdc20, an activator of the anaphase-promoting complex. Here, we have used different methods to investigate the association of RASSF1A and Cdc20. We show that there is no interaction between RASSF1A and Cdc20 and conclude that further investigation of the mitotic role of RASSF1A is required.

Source: Cell Cycle

DOI: 10.4161/cc.6.13.4435

Authors: Limin Liu, Katrin Baier, Reinhard H. Dammann, Gerd P. Pfeifer

Institutions: Beckman Research Institute, Martin Luther University Halle-Wittenberg

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute