Work

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Year: 2010

Type: article

Abstract: We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Source: Chemical Communications

DOI: 10.1039/c0cc02969f

Authors: Jason R. Porter, Mark R. Helmers, Ping Wang, Jennifer L. Furman, Stephen T. Joy, Paramjit S. Arora, Indraneel Ghosh

Institutions: University of Arizona, New York University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1656529444, G1906497346, Biomolecular Recognition with Artificial Alpha-Helices, SEER - a novel method for the detection of genetic sequences

OpenAlex ID: W1970475319

FWCI: 0.789

Cites: 35

Cited by: 14

Related to: 10