Work

Cell cycle regulation of human histone H1 mRNA.

Year: 1984

Type: article

Abstract: A cloned genomic DNA fragment containing a human histone H1 gene has been used to analyze histone H1 gene expression in two human cell lines (HeLa S3 and WI-38). The cellular abundance of histone H1 mRNA was compared with that of core (H2A, H2B, H3, and H4) histone mRNAs as a function of the cell cycle: core and H1 histone mRNA levels are related both to each other and to the apparent rate of DNA synthesis and are rapidly destabilized after DNA synthesis inhibition. The use of three synchronization protocols, and of transformed and normal diploid cells in culture, suggests that the detected core and H1 histone mRNA levels are regulated by similar mechanisms in continuously dividing human cell lines and nondividing cells stimulated to proliferate.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.81.2.434

Authors: M Plumb, F Marashi, L Green, A Zimmerman, S Zimmerman, J Stein, G Stein

Institutions: University of Florida Health, University of Florida

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, March of Dimes Foundation, National Institutes of Health

OpenAlex ID: W1970504454

FWCI: 3.797

Cites: 30

Cited by: 44

Related to: 10