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Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration

Year: 2011
Type: review
Abstract: Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch's membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE-derived mechanisms in AMD pathology.
DOI: 10.1111/j.1755-3768.2011.02179.x
Institutions: University of Eastern Finland, Kuopio University Hospital, University of Debrecen, Hungarian Academy of Sciences, Oslo University Hospital, University of Oslo
Language: English
Subfield: Ophthalmology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W1970528463
FWCI: 2.672
Cites: 182
Cited by: 196
Related to: 10