Work

How Steroids Steer T Cells

Year: 2014

Type: article

Abstract: Recent papers from Mahata et al. and Bereshchenko et al. reveal how steroids steer immune responses by tipping T helper (Th) subset balances and activities. Pregnenolone produced by Th2 cells mediates immunosuppressive responses, and glucocorticoids stimulate regulatory T cell development via the induction of GILZ expression.

Source: Cell Reports

DOI: 10.1016/j.celrep.2014.04.041

Authors: Claude Libert, Lien Dejager

Institutions: Vlaams Instituut voor Biotechnologie, Ghent University, VIB-UGent Center for Inflammation Research

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620