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A Multifactorial Mechanism in the Superior Antimalarial Activity of α -C-GalCer

Year: 2009
Type: article
Abstract: We have previously shown that the C-glycoside analog of alpha-galactosylceramide (alpha-GalCer), alpha-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, alpha-GalCer. In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by alpha-C-GalCer. Surprisingly, the diminished production of Th2 cytokines, including IL-4, by alpha-C-GalCer has no affect on its superior therapeutic activity relative to alpha-GalCer. Finally, we show that the in vivo administration of alpha-C-GalCer induces prolonged maturation of dendritic cells (DCs), as well as an enhanced proliferative response of mouse invariant Valpha14 (Valpha14i) NKT cells, both of which may also contribute to some degree to the superior activity of alpha-C-GalCer in vivo.
DOI: 10.1155/2010/283612
Institutions: Johns Hopkins University, Johns Hopkins Hospital, New York University, Memorial Sloan Kettering Cancer Center, Hunter College, Aaron Diamond AIDS Research Center
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $2,680
Funders: City University of New York, York University, National Institutes of Health, School of Medicine, New York University, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W1970627159
FWCI: 2.007
Cites: 40
Cited by: 13
Related to: 10