Work

G Protein-coupled Receptors

Year: 1998

Type: review

Abstract: The majority of transmembrane signal transduction in response to hormones and neurotransmitters is mediated by G protein-coupled receptors (GPCRs). 1 Moreover, GPCRs are the principal signal transducers for the senses of sight and smell. GPCRs are characterized by seven membrane-spanning domains with an extracellular N terminus and a cytoplasmic C terminus (Fig. 1) (GPCR structure reviewed in Refs.1-3). Based on certain key sequences, GPCRs can be divided into three major subfamilies, receptors related to rhodopsin (type A), receptors related to the calcitonin receptor (type B), and receptors related to the metabotropic receptors (type C).

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.273.29.17979

Authors: Ulrik Gether, Brian K. Kobilka

Institutions: University of Copenhagen, Stanford University, Howard Hughes Medical Institute, Stanford Medicine

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Institute of Neurological Disorders and Stroke