Work

Cell‐Responsive Synthetic Hydrogels

Year: 2003

Type: article

Abstract: Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐surface proteases, allowing cells to create paths for 3D cell migration (see Figure).

Source: Advanced Materials

DOI: 10.1002/adma.200304621

Authors: M.P. Lutolf, G.P. Raeber, A.H. Zisch, N. Tirelli, J.A. Hubbell

Institutions: University of Zurich, ETH Zurich, Institute for Biomedical Engineering

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1970751992

FWCI: 9.016

Cites: 34

Cited by: 526

Related to: 10