Polymorphisms in Inflammatory Genes are Associated with Term Small for Gestational Age and Preeclampsia
Year: 2014
Type: article
Study design: Observational Study
Abstract: PROBLEM: Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers. METHOD OF STUDY: Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets. RESULTS: Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% CI 1.1-2.7). CONCLUSION: Although previous studies have suggested null associations, increased tagging and stratification by genetic ancestry suggests important associations between IL6 and term SGA for African Americans, and a TNF regulator and PE among European Americans (N = 149).
DOI: 10.1111/aji.12241
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1017297203, G1339624411, IRON, ZINC AND FOLATE AND PRETERM DELIVERY, G251702431, EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY, G3578334320, General Clinical Research Center, G4899478068, G491315329, Placental Vascular Compromise and Preterm Delivery, Carolina Population Center, G738783015, Maternal Genetic Variation and Risk of Adverse Pregnancy Outcomes, UNC Center for Environmental Health and Susceptibility, Biostatistics for Research in Environmental Health
OpenAlex ID: W1970874206