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Concanamycin B Inhibits the Expression of Newly-synthesized MHC Class II Molecules on the Cell Surface.

Year: 1995
Type: article
Abstract: We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-gamma stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class I, MHC class II, and ICAM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it does not affect the expression of MHC class I and ICAM-1 molecules. Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes. Furthermore, concanamycin B suppresses the antigen presentation by MHC class II molecules.
DOI: 10.7164/antibiotics.48.488
Authors: KOUICHI ITO, TSUYOSHI KOBAYASHI, YOSHINORI MORIYAMA, KAZUNOBU TOSHIMA, KUNIAKI TATSUTA, TERUTAKA KAKIUCHI, MASAMITSU FUTAI, HIDDE L. PLOEGH, KIYOSHI MIWA
Institutions: F. Hoffmann-La Roche AG, Ajinomoto (Japan), The University of Osaka, Keio University, Toho University, Institute of Medical Science, The University of Tokyo, The University of Tokyo, Center for Cancer Research, Massachusetts Institute of Technology
Language: English
Subfield: Immunology
Open Access status: bronze
OpenAlex ID: W1970937430
FWCI: 0.572
Cites: 26
Cited by: 12
Related to: 10