Work

Early Human Screening of Medications to Treat Drug Addiction: Novel Paradigms and the Relevance of Pharmacogenetics

Year: 2011

Type: article

Abstract: Initial screening of medications for efficacy in treating drug dependence may be accomplished more efficiently by using novel approaches that combine the practical advantages of within-subject laboratory studies with the clinical validity provided by clinical trials. A priori selection of functional gene variants associated with the pharmacokinetic or pharmacodynamic effects of a medication may aid this effort by controlling for individual variability as to clinical response or adverse effects; however, there are limitations to this approach, and these should be carefully considered. Clinical Pharmacology & Therapeutics (2011) 89 3, 460–463. doi:10.1038/clpt.2010.254

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1038/clpt.2010.254

Authors: K A Perkins, C Lerman

Institutions: University of Pittsburgh, Abramson Cancer Center, University of Pennsylvania

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: AstraZeneca, National Institutes of Health, National Institute on Drug Abuse, National Cancer Institute