Work

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

Year: 2010

Type: article

Abstract: The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.

Source: Organic Letters

DOI: 10.1021/ol902764k

Authors: Bo Liang, Srinivas Kalidindi, John A. Porco, Corey R. J. Stephenson

Institution: Boston University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, Division of Chemistry

Award: Complex Chemotypes: Discovery, Methodology, and Library Expansion