Work

Microbiota Modulation of Myeloid Cells in Cancer Therapy

Year: 2015

Type: review

Abstract: Myeloid cells represent a major component of the tumor microenvironment, where they play divergent dual roles. They can induce antitumor immune responses, but mostly they promote immune evasion, tumor progression, and metastasis formation. Thus, strategies aiming at reprogramming the tumor microenvironment represent a promising immunotherapy approach. Myeloid cells respond to environmental factors including signals derived from commensal microbes. In this Cancer Immunology at the Crossroads overview, we discuss recent advances on the effects of the commensal microbiota on myeloid-cell functions and how they affect the response to cancer therapy.

Source: Cancer Immunology Research

DOI: 10.1158/2326-6066.cir-14-0225

Authors: Romina S. Goldszmid, Amiran Dzutsev, Sophie Viaud, Laurence Zitvogel, Nicholas P. Restifo, Giorgio Trinchieri