Work

Immune Reconstitution in Children Receiving Cord Blood Transplantation (CBT) Without the Use of Lymphocytolytic Antibodies

Year: 2012

Type: article

Abstract: Immune reconstitution following CBT can be prolonged and heighten the risk for infection. In this prospective study we substituted fludarabine for a lymphocytolytic antibody such as ATG or Campath with the intent of accelerating immune reconstitution and reducing the incidence of viral infections. Fifteen children (median age 12 months,range, 1 mo – 8 yr) with; Primary Immune Deficiency (n = 5), HLH (n = 1), alpha mannosidosis (n = 1), Fanconi Anemia (n = 1), Dyskeratosis Congenita (n = 1), SAA (n = 1) and acute leukemia (n = 5) were treated.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.190