Durable engraftment of AMD3100-mobilized hematopoietic stem cells in a canine autologous and allogeneic model
Year: 2005
Type: article
Abstract: AMD3100 is a synthetic molecule that inhibits binding of stromal cell–derived factor-1 to its receptor, CXCR4, expressed on hematopoietic cells. AMD3100 treatment of animals or humans results in mobilization of hematopoietic progenitor cells. Peripheral blood mononuclear cells (PBMCs) mobilized with a combination of AMD3100 plus G-CSF stably reconstituted autologous hematopoiesis in cancer patients following myeloablative conditioning. However, the engraftment potential of AMD3100-PBMC used alone has remained unproven.
Institutions: University of Washington, Fred Hutch Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1971302054