Work

From Histones to Ribosomes: A Chromatin Regulator Tangoes with Translation

Year: 2015

Type: article

Abstract: Summary: Histone lysine methylation is a critical regulator of chromatin-templated processes such as gene transcription and DNA repair, and is dynamically controlled by enzymes that write and erase this posttranslational modification. Although histone methylation has been well studied, the functions of nonhistone lysine methylation and its regulatory enzymes, particularly outside the nucleus, are poorly defined. In this issue of Cancer Discovery, Van Rechem and colleagues shed light on a new role for the lysine demethylase KDM4A as a regulator of protein translation and identify a single-nucleotide polymorphism in the KDM4A gene as a candidate biomarker for mTOR inhibitor therapy. Cancer Discov; 5(3); 228–30. ©2015 AACR. See related article by Van Rechem and colleagues, p. 245 See related article by Van Rechem and colleagues, p. 255

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-15-0073

Authors: Scott B. Rothbart, Bradley M. Dickson, Brian D. Strahl

Institutions: Van Andel Institute, University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences

Awards: Mechanisms Regulating DNA Methylation Maintenance in Chromatin, Discovery of Chemical Probes for Chromatin Readers, Mechanisms Regulating DNA Methylation Maintenance in Chromatin, Factors that regulate chromatin organization and gene transcription