Work

Nucleosome displacement in transcription: Figure 1.

Year: 2006

Type: preprint

Abstract: Recent reports reinforce the notion that nucleosomes are highly dynamic in response to the process of transcription. Nucleosomes are displaced at promoters during gene activation in a process that involves histone modification, ATP-dependent nucleosome remodeling complexes, histone chaperones and perhaps histone variants. During transcription elongation nucleosomes are acetylated and transferred behind RNA polymerase II where they are required to suppress spurious transcription initiation within the body of the gene. It is becoming increasingly clear that the eukaryotic transcriptional machinery is adapted to exploit the presence of nucleosomes in very sophisticated ways.

Source: Genes & Development

DOI: 10.1101/gad.1435706

Author: Jerry L. Workman

Institution: Stowers Institute for Medical Research

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Stowers Institute for Medical Research, National Institute of General Medical Sciences

Award: Mechanisms of Transcriptional Regulation in Chromatin