Work

Approaches toN-Methylwelwitindolinone C Isothiocyanate: Facile Synthesis of the Tetracyclic Core

Year: 2010

Type: article

Abstract: The synthesis of a functionalized, tetracyclic core of N-methylwelwitindolinone C isothiocyanate is reported. The approach features a convergent coupling between an indole iminium ion and a highly functionalized vinylogous silyl ketene acetal followed by an intramolecular palladium-catalyzed cyclization that proceeds via an enolate arylation.

Source: Organic Letters

DOI: 10.1021/ol1006373

Authors: Richard W. Heidebrecht, Brian Gulledge, Stephen F. Martin

Institution: The University of Texas at Austin

Language: English

Topic: Synthesis of Indole Derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G3647830492, Synthesis of Nitrogen Containing Natural Products