Work

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

Year: 2015

Type: article

Abstract: Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Source: Nano Letters

DOI: 10.1021/nl504044p

Authors: Hongmin Chen, Geoffrey D. Wang, Yen-Jun Chuang, Zipeng Zhen, Xiaoyuan Chen, Paul Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan, Jin Xie

Institutions: Harbin Medical University, University of Georgia, Fourth Affiliated Hospital of Harbin Medical University, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Augusta University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Elsa U. Pardee Foundation, National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, Ministry of Science and Technology of the People's Republic of China, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research

Awards: Laboratory of Molecular Imaging and Nanomedicine, Nanoplatform-based combinational therapy against breast cancer , G4952910785, G5094677207, G7236397983, G7520768619, G8713728176, G92131997

OpenAlex ID: W1971659905

FWCI: 17.76

Cites: 46

Cited by: 381

Related to: 10