Work

Triggered Sorting and Co‐Assembly of Genetically Engineered Protein Microdomains in the Cytoplasm

Year: 2013

Type: article

Abstract: Elastin-like polypeptides (ELPs) are genetically encoded protein polymers that reversibly phase separate in response to stimuli. They respond sharply to small shifts in temperature and form dense microdomains in the living eukaryotic cytosol. For the first time, this communication illustrates how to tune the ELP sequence and architecture for either co-assembly or sorting of distinct proteins into microdomains within a living cell.

Source: Advanced Materials

DOI: 10.1002/adma.201303356

Authors: Pu Shi, Yi‐An Lin, Martha Pastuszka, Honggang Cui, J. Andrew MacKay

Institutions: University of Southern California, Johns Hopkins University

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green