Drug Delivery for Treatment of Inner Ear Disease: Current State of Knowledge
Year: 2010
Type: review
Abstract: In Brief Delivery of medications to the inner ear has been an area of considerable growth in both the research and clinical realms during the past several decades. Systemic delivery of medication destined for treatment of the inner ear is the foundation on which newer delivery techniques have been developed. Because of systemic side effects, investigators and clinicians have begun developing and using techniques to deliver therapeutic agents locally. Alongside the now commonplace use of intratympanic gentamicin for Meniere's disease and the emerging use of intratympanic steroids for sudden sensorineural hearing loss, novel technologies, such as hydrogels and nanoparticles, are being explored. At the horizon of inner ear drug-delivery techniques, intracochlear devices that leverage recent advances in microsystems technology are being developed to apply medications directly into the inner ear. Potential uses for such devices include neurotrophic factor and steroid delivery with cochlear implantation, RNA interference technologies, and stem-cell therapy. The historical, current, and future delivery techniques and uses of drug delivery for treatment of inner ear disease serve as the basis for this review. Delivery of medications to the inner ear has been an area of considerable growth over the past several decades. Systemic delivery of medication destined for treatment of the inner ear is the foundation upon which newer delivery techniques have been developed. Investigators and clinicians have begun developing and utilizing techniques to deliver therapeutic agents locally. Intracochlear devices that leverage recent advances in microsystems technology are being developed to apply medications directly into the inner ear. The historical, current, and future delivery techniques and uses for inner ear drug delivery serve as the basis for this review.
Source: Ear and Hearing
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1972158701