Year: 1995
Type: review
Abstract: Although the one-dimensional sequence of DNA determines the genetic constitution of an organism, topological relationships within the double helix modulate virtually every physiological function of the genome(1, 2). In the cell, the topology of DNA is orchestrated by enzymes known as topoisomerases(1, 2, 3, 4, 5, 6, 7). These ubiquitous enzymes are required for replication, transcription, and recombination and play critical roles in chromosome structure, condensation/decondensation, and segregation(1, 2, 3, 4, 5, 6, 7, 8, 9).
Source: Journal of Biological Chemistry
Authors: Stacie J. Froelich-Ammon, Neil Osheroff
Institution: Vanderbilt University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1972227366