Work

Synthesis and Erosion Properties of PEG‐Containing Polyanhydrides

Year: 2007

Type: article

Abstract: To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content. Correspondingly, the erosion rate increases with increasing PEG content, whereas it decreases with increasing specimen thickness. This indicates that the incorporation of poly(ethylene glycol) into traditional two-component polyanhydrides retains their surface erosion properties while making the erosion rate tunable. The new polyanhydrides hold potential for drug delivery applications.

Source: Macromolecular Bioscience

DOI: 10.1002/mabi.200600256

Authors: Sijian Hou, Laurie K. McCauley, Peter X. Ma

Institution: University of Michigan

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Aeronautics and Space Administration, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research