Work

Nuclease Activity via Self-Activation and Anticancer Activity of a Mononuclear Copper(II) Complex: Novel Role of the Tertiary Butyl Group in the Ligand Frame

Year: 2012

Type: article

Abstract: The copper complex [Cu((t)BuPhimp)(Cl)] (1) derived from tridentate ligand (t)BuPhimpH having N(2)O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.

Source: Inorganic Chemistry

DOI: 10.1021/ic2016676

Authors: Kaushik Ghosh, Pramod Kumar, Varun Mohan, Udai P. Singh, Sahba Kasiri, Subhrangsu S. Mandal

Institutions: Indian Institute of Technology Roorkee, The University of Texas at Arlington

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Environmental Health Sciences

Award: Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism and