Work

Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs

Year: 2014

Type: review

Abstract: The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2014.00303

Authors: Masoud H. Manjili, Xiang-Yang Wang, Scott Abrams

Institutions: Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801