Work

Large-scale protein structure modeling of the Saccharomyces cerevisiae genome

Year: 1998

Type: article

Abstract: The function of a protein generally is determined by its three-dimensional (3D) structure. Thus, it would be useful to know the 3D structure of the thousands of protein sequences that are emerging from the many genome projects. To this end, fold assignment, comparative protein structure modeling, and model evaluation were automated completely. As an illustration, the method was applied to the proteins in the Saccharomyces cerevisiae (baker's yeast) genome. It resulted in all-atom 3D models for substantial segments of 1,071 (17%) of the yeast proteins, only 40 of which have had their 3D structure determined experimentally. Of the 1,071 modeled yeast proteins, 236 were related clearly to a protein of known structure for the first time; 41 of these previously have not been characterized at all.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.95.23.13597

Authors: Roberto Sánchez, Andrej Sali

Institutions: Rockefeller University, Brandeis University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G2967181944, PROTEIN MODELING BY SATISFACTION OF SPATIAL RESTRAINTS, Protein Modeling by Satisfaction of Spatial Restraints