Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion
Year: 2008
Type: review
Abstract: Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a homeostatic role at basal levels, and the absence of autophagy causes cardiac dysfunction and the development of cardiomyopathy. Autophagy is induced during myocardial ischemia and further enhanced by reperfusion. Although induction of autophagy during the ischemic phase is protective, further enhancement of autophagy during the reperfusion phase may induce cell death and appears to be detrimental. In this review we discuss the functional significance of autophagy and the underlying signaling mechanism in the heart during ischemia/reperfusion.
Source: Autophagy
DOI: 10.4161/auto.5638
Authors: Yutaka Matsui, Shiori Kyoi, Hiromitsu Takagi, Chiao-Po Hsu, Nirmala Hariharan, Tetsuro Ago, Stephen F. Vatner, Junichi Sadoshima
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
Awards: 'Death'and 'MAPK'pathways with myocardial ischemia, Regulation of myocardial growth and death by GSK-3, G5103921932, G5538412199, Myocardial Hypertrophy and Heart Failure, G605350398, Cardiovascular Control in Normal and Disease States, G7295199721, Mechanisms of myocardial ischemia and reperfusion
OpenAlex ID: W1972557061