A Potent Trivalent Sialic Acid Inhibitor of Adenovirus Type 37 Infection of Human Corneal Cells
Year: 2011
Type: article
Abstract: Wouldn′t it be useful to have three arms? It came in handy for a trivalent sialic acid inhibitor, which blocked all three binding pockets of a trimeric adenoviral fiber-knob protein and thus prevented cell attachment and the subsequent infection of human corneal epithelial cells. The picture shows the terminal sialic acid moietes of the inhibitor bound to the top of the fiber head (C yellow, O red, N blue; the spacers and scaffold are not shown).
Authors: Sara Spjut, Weixing Qian, Johannes Bauer, Rickard Storm, Lars Frängsmyr, Thilo Stehle, Niklas Arnberg, Mikael Elofsson
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1972628981