Work

Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO

Year: 2009

Type: article

Abstract: A light-activated NO donor, [Mn(PaPy(3))(NO)]ClO(4) (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1a(x) · HG and 1a(x) · HG(MB) have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1a(x) · HG(MB) could be used as wound dressings that deliver NO under controlled conditions.

Source: Journal of Materials Science Materials in Medicine

DOI: 10.1007/s10856-009-3795-0

Authors: Genevieve M. Halpenny, Rachel C. Steinhardt, Krystle A. Okialda, Pradip K. Mascharak

Institution: University of California, Santa Cruz

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $2,590

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry