Work

Hydrophobic cluster analysis: An efficient new way to compare and analyse amino acid sequences

Year: 1987

Type: article

Abstract: A new method for comparing and aligning protein sequences is described. This method, hydrophobic cluster analysis (HCA), relies upon a two-dimensional (2D) representation of the sequences. Hydrophobic clusters are determined in this 2D pattern and then used for the sequence comparisons. The method does not require powerful computer resources and can deal with distantly related proteins, even if no 3D data are available. This is illustrated in the present report by a comparison of human haemoglobin with leghaemoglobin, a comparison of the two domains of liver rhodanese (thiosulphate sulphurtransferase) and a comparison of plastocyanin and azurin.

Source: FEBS Letters

DOI: 10.1016/0014-5793(87)80439-8

Authors: C. Gaboriaud, V. Bissery, T. Benchetrit, J.P. Mornon

Institutions: Centre National de la Recherche Scientifique, Inserm

Language: English

Topic: Fractal and DNA sequence analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique

OpenAlex ID: W1972961211

FWCI: 4.066

Cites: 19

Cited by: 627

Related to: 10