Work

Collaboration and competition between DNA double‐strand break repair pathways

Year: 2010

Type: review

Abstract: DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair. The two major pathways involved in the repair of double-strand breaks in eukaryotic cells are non-homologous end joining and homologous recombination. Numerous factors affect the decision to repair a double-strand break via these pathways, and accumulating evidence suggests these major repair pathways both cooperate and compete with each other at double-strand break sites to facilitate efficient repair and promote genomic integrity.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2010.07.057

Authors: Elizabeth M. Kass, Maria Jasin

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Program Project in Models of Breast Cancer, Double-strand break repair and Translocations in mammalian cells