Work

Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds

Year: 2012

Type: article

Abstract: Ene-reductases from the 'Old Yellow Enzyme' family of flavoproteins catalyze the asymmetric reduction of various α,β-unsaturated compounds at the expense of a nicotinamide cofactor. They have been applied to the synthesis of valuable enantiopure products, including chiral building blocks with broad industrial applications, terpenoids, amino acid derivatives and fragrances. The combination of these highly stereoselective biocatalysts with a cofactor recycling system has allowed the development of cost-effective methods for the generation of optically active molecules, which is strengthened by the availability of stereo-complementary enzyme homologues.

Source: Journal of Biotechnology

DOI: 10.1016/j.jbiotec.2012.03.023

Authors: Christoph K. Winkler, Gábor Tasnádi, Dorina Clay, Mélanie Hall, Kurt Faber

Institutions: University of Graz, Austrian Centre of Industrial Biotechnology (Austria)

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,141