Work

Enantioselective Intramolecular Openings of Oxetanes Catalyzed by (salen)Co(III) Complexes: Access to Enantioenriched Tetrahydrofurans

Year: 2009

Type: article

Abstract: The catalytic enantioselective intramolecular ring-opening of oxetanes with alcohols is catalyzed by (salen)Co(III) complexes. Either a monomeric or oligomeric catalyst can be used successfully in this transformation, providing 3-substituted tetrahydrofurans in both high yield and enantioselectivity. This methodology extends the range of electrophiles that can be activated toward highly enantioselective addition reactions by (salen)metal catalysts to an important new class.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja809176m

Authors: Rebecca N. Loy, Eric N. Jacobsen

Institution: Harvard University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G2091016619, Chiral Complexes Designed to Catalyzed Organic Reactions, Chiral Catalysts Designed to Catalyze Organic Reactions