Sono-activated ultrasound localization microscopy
Year: 2013
Type: article
Abstract: Scanned at very high ultrasound frame rates, injectable microbubbles can be activated sequentially as isolated punctual sources of acoustic echoes. These signals can thus be localized far beyond the diffraction limit. The resolution improvement granted by Sono-Activated Ultrasound Localization Microscopy (SAULM) was demonstrated within microfluidic channels 20 times smaller than the imaging wavelength (λ = 870 μm). The width of the channels mapped with SAULM was 13 times smaller than as they appeared under conventional ultrasound imaging. Two channels separated by λ/4.5 could be distinguished. Implementing SAULM in-vivo could lead to a complete reconstruction of the vascular tree down to the smallest capillaries at several centimeter depth.
Source: Applied Physics Letters
DOI: 10.1063/1.4826597
Authors: Yann Desailly, Olivier Couture, Mathias Fink, Mickael Tanter
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1973042235