Work

Size Matters: Gold Nanoparticles in Targeted Cancer Drug Delivery

Year: 2012

Type: review

Abstract: Cancer is the current leading cause of death worldwide, responsible for approximately one quarter of all deaths in the USA and UK. Nanotechnologies provide tremendous opportunities for multimodal, site-specific drug delivery to these disease sites and Au nanoparticles further offer a particularly unique set of physical, chemical and photonic properties with which to do so. This review will highlight some recent advances, by our laboratory and others, in the use of Au nanoparticles for systemic drug delivery to these malignancies and will also provide insights into their rational design, synthesis, physiological properties and clinical/preclinical applications, as well as strategies and challenges toward the clinical implementation of these constructs moving forward.

Source: Therapeutic Delivery

DOI: 10.4155/tde.12.21

Authors: Erik C Dreaden, Lauren A Austin, Megan A Mackey, Mostafa A El-Sayed

Institutions: Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Georgia Institute of Technology

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute