Work

A Preclinical Murine Model of Hepatic Metastases

Year: 2014

Type: article

Abstract: Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

Source: Journal of Visualized Experiments

DOI: 10.3791/51677

Authors: Kevin C. Soares, Kelly Foley, Kelly Olino, Ashley Leubner, Skye C. Mayo, Ajay Jain, Elizabeth Jaffee, Richard D. Schulick, Kiyoshi Yoshimura, Barish Edil, Lei Zheng

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center, University of Colorado Anschutz

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1324540468, Interrogate the interaction between tumor cells and nerves in the tumor microenvironment of pancreatic cancer, Dissecting the mechanisms of immune tolerance within the pancreatic tumor's micro, SPORE in Gastrointestinal Cancers, Cellular and Molecular Medicine, Clinical and Laboratory Research Training for Gastrointestinal Surgeons

OpenAlex ID: W1973087765

FWCI: 3.015

Cites: 13

Cited by: 129

Related to: 10