Work

High-Speed Ultrahigh-Resolution OCT of Bruch’s Membrane in Membranoproliferative Glomerulonephritis Type 2

Year: 2014

Type: article

Abstract: Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

Source: Ophthalmic surgery, lasers & imaging retina

DOI: 10.3928/23258160-20141118-20

Authors: Mehreen Adhi, Sarah P. Read, Jonathan J. Liu, James G. Fujimoto, Jay S. Duker

Institutions: Tufts Medical Center, Massachusetts Institute of Technology

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Research to Prevent Blindness, National Institutes of Health, National Eye Institute