The brain‐derived neurotrophic‐factor ( BDNF ) val66met polymorphism is associated with geriatric depression: A meta‐analysis
Year: 2012
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes (P = 0.004, OR = 1.48, 95% CI = 1.13-1.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age.
DOI: 10.1002/ajmg.b.32062
Authors: Yu Pei, Alicia K. Smith, Yongjun Wang, Yanli Pan, Jian Yang, Qi Chen, Weigang Pan, Feng Bao, Lisha Zhao, Changle Tie, Yizheng Wang, Jian Wang, Wenfeng Zhen, Jinxia Zhou, Xin Ma
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1973114890