Work

Atomic force microscopy of electrospun organic-inorganic lipid nanofibers

Year: 2011

Type: article

Abstract: An organic-inorganic hybridization strategy has been proposed to synthesize polymerizable lipid-based materials for the creation of highly stable lipid-mimetic nanostructures. We employ atomic force microscopy (AFM) to analyze the surface morphology and mechanical property of electrospun cholesteryl-succinyl silane (CSS) nanofibers. The AFM nanoindentation of the CSS nanofibers reveals elastic moduli of 55.3 ± 27.6 to 70.8 ± 35 MPa, which is significantly higher than the moduli of natural phospholipids and cholesterols. The study shows that organic-inorganic hybridization is useful in the design of highly stable lipid-based materials.

Source: Applied Physics Letters

DOI: 10.1063/1.3635783

Authors: Jinhong Zhang, Celine Cohn, Weiguo Qiu, Zhengbao Zha, Zhifei Dai, Xiaoyi Wu

Institutions: University of Arizona, BIO5 Institute, Harbin Institute of Technology, State Key Laboratory of Urban Water Resources and Water Environment

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Cardiovascular Biomedical Engineering Training Grant, Microsystem-based Formation of Recombinant Protein Fibers