Work

DNA repair proteins affect the lifecycle of herpes simplex virus 1

Year: 2005

Type: article

Abstract: We report that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells. Early in HSV-1 infection, several members of the cellular DNA damage-sensing machinery are activated and accumulate at sites of viral DNA replication. When this cellular response is abrogated, formation of HSV-1 replication centers is retarded, and viral production is compromised. In neurons, HSV-1 replication centers fail to mature, and the DNA damage response is not initiated. These data suggest that the failure of neurons to mount a DNA damage response to HSV-1 may contribute to the establishment of latency.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0501916102

Authors: Caroline E. Lilley, Christian T. Carson, Alysson R. Muotri, Fred H. Gage, Matthew D. Weitzman

Institutions: Salk Institute for Biological Studies, University of California San Diego

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, G. Harold and Leila Y. Mathers Foundation, National Institutes of Health