Gd‐Labeled Microparticles in MRI: In vivo Imaging of Microparticles After Intraperitoneal Injection
Year: 2010
Type: article
Abstract: To visualize the biodistribution of porous silica microparticles in vivo, known ligands are used to immobilize gadolinium in the pores for use as MRI contrast agents. MRI studies with rodents show that a fraction of the microparticles administered by intraperitoneal injection passed through the kidneys by an unknown mechanism and are, surprisingly, excreted via the urine. Analysis of the urine with SEM and energy dispersive spectroscopy corroborated the MRI results.
Source: Small
Institutions: University of Vermont, Dartmouth–Hitchcock Medical Center
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1973234551