Work

Is the term "exuberant hypertrophy" inappropriate? a 4-year AHA pre and post-aortic valve replacement CMR study

Year: 2010

Type: article

Abstract: After recruitment of 35 pts for a 2-year Cardiac MRI (CMR) study, a subgroup were re-recruited up to 4 years post-AVR. All pts underwent 3D volumetrics, LV mass and 3D EF (GE 1.5 T, WI) stratified by gender. Ten pts were available for CMR at 3 ± 1 yrs out to 4 years post-AVR for CMR. Woman (6; age: 68 ± 14) and men (4; age: 68 ± 10); were imaged. Baseline LV mass index was neither increased in females nor different between woman and men (75 ± 16 vs. 101 ± 23 g/m , p = NS). However, baseline EF was dissimilar between woman and men (67 ± 12 vs. 37 ± 23%, p = NS). Following AVR, in absolute or relative terms, LV mass regression was not different between sexes (65 ± 17 vs. 73 ± 11 g/m ; representing a proportionate decrease in LV mass of 11 ± 16 vs. 28 ± 17 g/m , p = NS). Likewise, post-AVR, LVEF was not different (68 ± 7 vs. 61 ± 10%, p = NS) but did markedly improve in males (1 ± 10 vs. 24 ± 20%, p < 0.05), again without absolute change in LV mass index between gender. While conceptually intriguing and highly controversial, the gender-based differences of exaggerated LVH formation in response to pressure afterload that are based substantially on echocardiography appear to be artificial when based upon 3D CMR interrogation. The potential socio-economic repercussions, should a more disparate response to afterload have been found (either at baseline or after AVR), are nullified.

Source: Journal of Cardiovascular Magnetic Resonance

DOI: 10.1186/1532-429x-12-s1-p290