Year: 1974
Type: article
Abstract: Carbachol (carbamycholine chloride) (28 nmol) was injected on 77 occasions into 69 loci in the hypothalamus of 13 sheep.Of the injections, 31% elicited feeding, 14% elicited drinking, and 4% elicited both feeding and drinking responses.One carbachol feeding locus in each of eight sheep was injected with carbachol at doses from 1.75 to 112 nmol.Feeding was elicited by 3.5 nmol or more carbachol.At carbachol-bound feeding loci in eight sheep, the effect of carbachol was blocked by atropine, a cholinergic antagonist, but not by phenoxybenzamine or LB-46, a and fladrenoceptor antagonists, respectively; atropine alone had no effect.Increases in water intake accompanying carbachoIinduced feeding may be due to increased dry matter intake.There were no significant effects on intraperi, toneal temperature.Cholinergic pathways passing through the hypothalamus of sheep is proposed as an explanation for the feeding.
Source: Journal of Dairy Science
Authors: J.M. Forbes, C.A. Baile
Institution: University of Pennsylvania
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
SDG: Zero hunger
Open Access status: bronze
Funder: National Science Foundation
OpenAlex ID: W1973483726