Work

Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers

Year: 2009

Type: article

Abstract: We demonstrate a new enzyme-induced disassembly of amphiphilic nanocontainers based on dendrimers. Disassembly and the ensuing release of noncovalently bound guest molecules are of great interest because of their implications in areas such as drug delivery and sensing. Achieving these with a protein as the stimulus is of even greater importance, because proteins are the primary indicators of biological imbalances. We achieved disassembly of the nanocontainers by disturbing the hydrophilic-lipophilic balance in the amphiphilic dendrimer building blocks.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja906162u

Authors: Malar A. Azagarsamy, Punidha Sokkalingam, S. Thayumanavan

Institution: University of Massachusetts Amherst

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Amphiphilic Dendrimers for Encapsulation and Release