Year: 2010
Type: article
Abstract: p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool.
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,110
Funders: Multiple Myeloma Research Foundation, Philip Morris International, Fondazione Telethon, Ministero dell’Istruzione, dell’Università e della Ricerca, Associazione Italiana per la Ricerca sul Cancro, Alleanza Contro il Cancro, National Institutes of Health, Medical Research Council, National Cancer Institute, National Institute of General Medical Sciences
Awards: Regulation of the cell cycle by CRL ubiquitin ligases, Epithelial Stem Cell Programs, G2326773006, G3449365268, G3699029709, Novel Substrates of SCF Ubiquitin Ligases in Cell Cycle Control and Cancer, G6913103108, G7955387765, G8038360977, F-box proteins: deregulated cell cycle control and proteolysis in cancer, G8950987567, G9000150878, G9000166399, G9000258358, G9000386135
OpenAlex ID: W1973528887