Work

Progress in The Development of Paper-Based Diagnostics for Low-Resource Point-Of-Care Settings

Year: 2013

Type: review

Abstract: This Review focuses on recent work in the field of paper microfluidics that specifically addresses the goal of translating the multistep processes that are characteristic of gold-standard laboratory tests to low-resource point-of-care settings. A major challenge is to implement multistep processes with the robust fluid control required to achieve the necessary sensitivity and specificity of a given application in a user-friendly package that minimizes equipment. We review key work in the areas of fluidic controls for automation in paper-based devices, readout methods that minimize dedicated equipment, and power and heating methods that are compatible with low-resource point-of-care settings. We also highlight a focused set of recent applications and discuss future challenges.

Source: Bioanalysis

DOI: 10.4155/bio.13.243

Authors: Samantha Byrnes, Gregory Thiessen, Elain Fu

Institution: University of Washington

Language: English

Topic: Biosensors and Analytical Detection

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Award: A high-sensitivity low-cost multiplexed immunoassay platform based on 2-dimension