Work

1049. Regenerative Cell Therapy for White Matter Disorders

Year: 2006

Type: article

Abstract: We tested the therapeutic potential of neurospheres generated from GFP transgenic rats as regenerative therapy for white matter diseases. We previously reported that postnatal derived rat neurospheres generate more than 50% oligodendrocytes in vitro. GFP+ postnatal neurospheres were transplanted into the corpus callosum of chemically induced demyelination rat model and in a Canavan rat model (Tremor rat caused by a deletion of the Aspa gene) with the aim to repopulate the brain with white matter producing oligodendrocytes.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.1145

Authors: Ana Olariu, Jeremy Francis, Scott McPhee, Eiji Kobayashi, Paola Leone

Institution: Jichi Medical University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500